Cardiac electrophysiology & electromechanics · v5.12
HeartSim simulates activation propagation, electrograms, the 12-lead ECG, and wall mechanics across eleven pathology presets, on full epicardial and endocardial meshes, with every parameter grounded in published literature.
What it simulates
Start with tissue, propagate an activation front through it, and read out every signal a clinician or researcher would recognize, electrical and mechanical, chamber by chamber.
Chamber-isolated eikonal / fast-marching propagation with transmural coordinates, producing local activation times you can trust down to the segment.
Unipolar and bipolar electrograms reconstructed from the moving wavefront across an array of up to 256 electrodes.
Separate atrial and ventricular dipoles generate a physiologically consistent surface ECG, not a template overlay.
A Land contraction model drives displacement, global longitudinal strain, ejection fraction, and bull's-eye strain maps.
Scar, fibrosis, conduction block, and conduction-velocity fields define the tissue the wavefront actually has to move through.
Endocardium-to-epicardium activation delay scales with local conduction velocity, giving realistic transmural timing.
Under the hood
HeartSim couples established electrophysiological and mechanical models so that each output follows from the physics of the one before it.
Pathology library
Each preset produces a physiologically plausible substrate with its own scar, fibrosis, block, and conduction-velocity signature, validated so that no two look alike.
Healthy baseline conduction and mechanics.
Established scar with a slow-conducting border zone.
Anterior infarct territory and regional wall-motion loss.
Delayed left-ventricular activation and dyssynchrony.
Delayed right-ventricular activation sequence.
Fibrotic atrial substrate supporting reentry.
Arrhythmogenic right-ventricular fibro-fatty replacement.
Right-ventricular outflow-tract repolarization abnormality.
Accessory pathway with ventricular pre-excitation.
Hypertrophied wall with altered mechanics.
Scar-related reentrant ventricular tachycardia circuit.
Grounded in the literature
Model parameters aren't tuned by feel. Transmural gradients, regional mechanics, and activation timing are tied to specific published work.
Where it sits
On the horizon
The core simulation is stable and cross-platform. These are the capabilities in active development.
Paint scar directly onto the mesh with an ablation brush and re-simulate VT termination in place. An optional Pennes bioheat + Arrhenius path models true thermal lesions.
Recover activation timing from imaging-derived strain, onset-of-shortening as an LAT surrogate, EWI-style, then drive a forward ECG from the reconstructed sequence.
Ingest high-resolution PCCT geometry as simulation input, bringing patient-specific anatomy into the pipeline.
Built to run in your lab
HeartSim runs as a real desktop tool with GPU-accelerated 3D rendering, engineered for stability on both primary research operating systems.
Request research access, or book a walkthrough with the Innovatech Health team to run your own geometry through the pipeline.